Peculiarities of Determining Bacterial Endotoxins in Oil Solutions of Drugs

Isolation
DOI: 10.1007/s11094-020-02234-7 Publication Date: 2020-08-20T09:04:01Z
ABSTRACT
Issues related to reliable quality assessment of oil solutions of medicines with respect to the Bacterial Endotoxins indicator are considered. The maximum isolation of bacterial endotoxins from fat-soluble drugs for subsequent determination is assisted by vigorous stirring of samples in water previously heated to 60°C followed by separation of the two phases using centrifugation at 2300 rpm for 10 min.
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