Controlled Release from Zein Matrices: Interplay of Drug Hydrophobicity and pH

• DOI: 10.1007/s11095-015-1818-8
• Publication Date: 2015-11-18T16:50:57Z
• Authors: Jacob Bouman; Peter Belton; Paul Venema; Erik van der Linden; Renko de Vries; Sheng Qi
• Keywords: Excipient; Liberation

In earlier studies, the corn protein zein is found to be suitable as a sustained release agent, yet range of drugs for which has been studied remains small. Here, used sole excipient differing in hydrophobicity and isoelectric point: indomethacin, paracetamol ranitidine. Caplets were prepared by hot-melt extrusion (HME) injection moulding (IM). Each three model tested on two drug loadings various dissolution media. The physical state drug, microstructure hydration behaviour investigated build up understanding from based matrix delivery. Drug crystallinity caplets increases with hydrophobicity. For ranitidine swelling rates, capacity rates pH dependent consequence presence charged groups molecules. Both could approached existing models. dependant electrostatic interactions are hypothesised influence kinetics. factors can potentially kinetics release, thereby broadening horizon tuneable agent.