Recruitment of participants through community pharmacies for a pharmacogenetic study of antihypertensive drug treatment

• DOI: 10.1007/s11096-008-9264-x
• Publication Date: 2008-11-29T08:49:30Z
• Authors: Diane B. M. A. Wi...; Anke-Hilse Maitla...; Anthonius Boer; Bruno H. Ch. Stri...; Abraham A. Kroon; Peter W. Leeuw; O. Bozkurt; Olaf H. Klungel
• Keywords: Antihypertensive drug

To describe the design, recruitment and baseline characteristics of participants in a community pharmacy based pharmacogenetic study antihypertensive drug treatment.Participants enrolled from population-based Pharmaco-Morbidity Record Linkage System.We designed nested case-control which we will assess whether specific genetic polymorphisms modify effect drugs on risk myocardial infarction. In this study, cases (myocardial infarction) controls were recruited through pharmacies that participate PHARMO. The PHARMO database comprises dispensing histories about 2,000,000 subjects representative sample Dutch linked to national registrations hospital discharges.In total selected 31010 patients (2777 28233 controls) database, whom 15973 (1871 cases, 14102 approached their pharmacy. Overall response rate was 36.3% (n = 5791, 794 4997 controls), whereas 32.1% 5126, 701 4425 gave informed consent genotype DNA. As expected, several cardiovascular factors such as smoking, body mass index, hypercholesterolemia, diabetes mellitus more common than controls.Furthermore, often used beta-blockers calcium-antagonists, thiazide diuretics, ACE-inhibitors, angiotensin-II receptor blockers. We have demonstrated it is feasible select coded for approach them pharmacies, achieving reasonable rates without violating privacy rules.