Drug-induced anaphylaxis in China: a 10 year retrospective analysis of the Beijing Pharmacovigilance Database
Mucocutaneous zone
DOI:
10.1007/s11096-017-0535-2
Publication Date:
2017-10-31T01:26:25Z
AUTHORS (8)
ABSTRACT
Background Few studies on the causes of drug-induced anaphylaxis (DIA) in hospital setting are available. Objective We aimed to use Beijing Pharmacovigilance Database (BPD) identify DIA Beijing, China. Setting Anaphylactic case reports from BPD provided by Center for Adverse Drug Reaction Monitoring. Method cases collected January 2004 December 2014 were adjudicated. Cases analyzed demographics, causative drugs and route administration, clinical signs outcomes. Main outcome measure Drugs implicated DIAs identified symptoms analyzed. Results A total 1189 The mean age was 47.6 years, 732 (61.6%) aged 18 59 years. 627 patients (52.7%) females. There a predominance cardiovascular (83.8%) followed respiratory (55.4%), central nervous (50.1%), mucocutaneous (47.4%), gastrointestinal (31.3%). 249 different involved. mainly caused antibiotics (39.3%), traditional Chinese medicines (TCM) (11.9%), radiocontrast agents antineoplastic (10.3%). Cephalosporins accounted majority (34.5%) antibiotic-induced anaphylaxis, fluoroquinolones (29.6%), beta-lactam/beta-lactamase inhibitors (15.4%) penicillins (7.9%). Blood products biological (3.1%), plasma substitutes (2.1%) also important contributors DIAs. Conclusion variety drug classes Patients should be closely monitored when medications administered especially with antibiotics, TCM, agents.
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