Hypolipidemic and Antioxidative Effects of Noni (Morinda citrifolia L.) Juice on High- fat/Cholesterol-Dietary Hamsters

• DOI: 10.1007/s11130-012-0309-x
• Publication Date: 2012-11-10T17:52:43Z
• Authors: Yi-Ling Lin; Chung-Hsi Chou; Deng-Jye Yang; Jr-Wei Chen; Bor-Show Tzang; Yi-Chen Chen
• Keywords: Male; 2. Zero hunger; 0301 basic medicine; 0303 health sciences; Gene Expression; Atherosclerosis; Diet, High-Fat; Lipid Metabolism; Dietary Fats; Glutathione; Antioxidants; Ion Channels; Beverages; Cholesterol, Dietary; Mitochondrial Proteins; Feces; 03 medical and health sciences; Liver; Cricetinae; Fruit; Malondialdehyde; Dietary Supplements; Animals; Hypolipidemic Agents

Noni juice (NJ) is rich in phytochemicals and polysaccharides. Lipid-lowering and antioxidative effects of NJ were investigated in this study. Fifty male hamsters were assigned randomly to one of the following groups: (1) normal diet and distilled water (LFCD); (2) high-fat/cholesterol diet and distilled water (HFCD); (3) HFCD and 3 ml NJ (including 0.20 g solids)/kg BW (NJ_L); (4) HFCD and 6 mL NJ (including 0.40 g solids)/kg BW (NJ_M); (5) HFCD and 9 ml NJ (including 0.60 g solids)/kg BW (NJ_H) for six weeks. NJ supplementation decreased (p < 0.05) serum triacylglycerol, cholesterol, atherogenic index, malondialdehyde levels, and hepatic lipids in HFCD hamsters, whereas serum trolox equivalent antioxidant capacity, glutathione, and fecal lipids in HFCD hamsters were increased (p < 0.05) by NJ supplementation. Although NJ supplementation downregulated (p < 0.05) sterol regulator element binding protein-1c in HFCD hamsters, it upregulated (p < 0.05) hepatic peroxisome proliferator-activated receptor-alpha and uncoupling protein 2 gene expressions in HFCD hamsters. Results demonstrate that NJ promotes cardioprotection in a high-fat/cholesterol diet.