Hypolipidemic and Antioxidative Effects of Noni (Morinda citrifolia L.) Juice on High- fat/Cholesterol-Dietary Hamsters

Male 2. Zero hunger 0303 health sciences Gene Expression Atherosclerosis Diet, High-Fat Lipid Metabolism Dietary Fats Glutathione Antioxidants Ion Channels Beverages Cholesterol, Dietary Mitochondrial Proteins Feces 03 medical and health sciences Liver Cricetinae Fruit Malondialdehyde Dietary Supplements Animals Hypolipidemic Agents
DOI: 10.1007/s11130-012-0309-x Publication Date: 2012-11-10T17:52:43Z
ABSTRACT
Noni juice (NJ) is rich in phytochemicals and polysaccharides. Lipid-lowering and antioxidative effects of NJ were investigated in this study. Fifty male hamsters were assigned randomly to one of the following groups: (1) normal diet and distilled water (LFCD); (2) high-fat/cholesterol diet and distilled water (HFCD); (3) HFCD and 3 ml NJ (including 0.20 g solids)/kg BW (NJ_L); (4) HFCD and 6 mL NJ (including 0.40 g solids)/kg BW (NJ_M); (5) HFCD and 9 ml NJ (including 0.60 g solids)/kg BW (NJ_H) for six weeks. NJ supplementation decreased (p < 0.05) serum triacylglycerol, cholesterol, atherogenic index, malondialdehyde levels, and hepatic lipids in HFCD hamsters, whereas serum trolox equivalent antioxidant capacity, glutathione, and fecal lipids in HFCD hamsters were increased (p < 0.05) by NJ supplementation. Although NJ supplementation downregulated (p < 0.05) sterol regulator element binding protein-1c in HFCD hamsters, it upregulated (p < 0.05) hepatic peroxisome proliferator-activated receptor-alpha and uncoupling protein 2 gene expressions in HFCD hamsters. Results demonstrate that NJ promotes cardioprotection in a high-fat/cholesterol diet.
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