Design of small-molecule thrombin inhibitors based on the cis-5-phenylproline scaffold

• DOI: 10.1007/s11172-011-0107-x
• Publication Date: 2011-10-28T21:28:46Z
• Authors: K. V. Kudryavtsev; D. A. Shulga; V. I. Chupakhin; A. V. Churakov; N. G. Datsuk; D. V. Zabolotnev; N. S. Zefirov
• Keywords: Amidine; Guanidine; Docking (animal)

AbstractMolecular docking studies, analysis of ligand‐protein interactions, followed by multistage targeted syntheses and biochemical investigations provide a series of novel nonbasic small‐molecule compounds based on the cis‐5‐phenylproline molecular scaffold.