Synthesis of new fluorine-containing pyrazolo[3,4-b]pyridinones as promising drug precursors

• DOI: 10.1007/s11172-011-0114-y
• Publication Date: 2011-10-29T01:28:46Z
• Authors: A. S. Golubev; G. S. Starostin; K. S. Chunikhin; A. S. Peregudov; K. C. Rodygin; S. A. Rubtsova; P. A. Slepukhin; A. V. Kuchin; N. D. Chkanikov
• Keywords: 01 natural sciences; 0104 chemical sciences

AbstractThe approaches to the synthesis of earlier unknown title compounds containing the 4‐ArSCF2 and 4‐ArSCHF groups involve i) direct annulation of substituted aminopyrazoles (I) with halogenated acetoacetates like (II), (V), and (X), and ii) replacement of the Br atom of the 4‐CF2Br group, or the Cl atom of the 4‐CHFCl group by sodium arenethiolates (VII) and (XII).