Synthesis of lupane triterpenoids with triphenylphosphonium substituents and studies of their antitumor activity

0301 basic medicine 03 medical and health sciences 01 natural sciences 0104 chemical sciences
DOI: 10.1007/s11172-013-0028-y Publication Date: 2013-10-22T07:26:10Z
ABSTRACT
New derivatives of lupane triterpenoids, viz., 20,29-dihydrobetulinic and 3-epi-20,29-dihydrobetulinic acid derivatives containing triphenylphosphonium fragments as substituents were synthesized. These compound considerably exceed betulinic acid in antitumor activity.
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