Synthesis of lupane triterpenoids with triphenylphosphonium substituents and studies of their antitumor activity

• DOI: 10.1007/s11172-013-0028-y
• Publication Date: 2013-10-22T07:26:10Z
• Authors: A. Yu. Spivak; D. A. Nedopekina; E. R. Shakurova; R. R. Khalitova; R. R. Gubaidullin; V. N. Odinokov; U. M. Dzhemilev; Yu. P. Bel’skii; N. V. Bel’skaya; S. A. Stankevich; E. V. Korotkaya; V. A. Khazanov
• Keywords: 0301 basic medicine; 03 medical and health sciences; 01 natural sciences; 0104 chemical sciences

New derivatives of lupane triterpenoids, viz., 20,29-dihydrobetulinic and 3-epi-20,29-dihydrobetulinic acid derivatives containing triphenylphosphonium fragments as substituents were synthesized. These compound considerably exceed betulinic acid in antitumor activity.