Formation and pharmacological activity of silicon—chitosan-containing glycerohydrogels obtained by biomimetic mineralization

• DOI: 10.1007/s11172-015-1053-9
• Publication Date: 2016-05-04T06:30:46Z
• Authors: E. V. Shadrina; O. N. Malinkina; T. G. Khonina; A. B. Shipovskaya; V. I. Fomina; E. Yu. Larchenko; N. A. Popova; I. G. Zyryanova; L. P. Larionov
• Keywords: Silanol

The biomimetic sol—gel synthesis of silicon—chitosan-containing glycerohydrogels was carried out using silicon tetraglycerolate as a precursor. It was found that chitosan accelerates gel formation in weakly acidic media. In more acidic media, the kinetics of the process changes according to the curve with a maximum, which can be attributed to different mechanisms of silanol condensation before and after the isoelectric point. The investigated silicon—chitosan-containing glycerohydrogels exhibit antibacterial, anti-inflammatory, and wound healing activity. The synthesized hybrid glycerohydrogels are promising materials for biomedical applications.