Synthesis of new acridine-9-carboxylic acid derivatives

• DOI: 10.1007/s11172-018-2152-1
• Publication Date: 2018-08-20T09:53:02Z
• Authors: V. V. Melyshenkova; D. N. Kuznetsov; A. G. Ruchkina; K. I. Kobrakov
• Keywords: 01 natural sciences; 0104 chemical sciences

New 1,3-dihydroxyacridine-9-carboxylic acids were obtained by Pfitzinger reaction from 2,4,6-trihydroxytoluene (methylphloroglucinol). Their bromination and azo-coupling reactions were studied. Computer simulation was used to determine potential pharmacokinetic and toxic properties of the synthesized compounds.