Kinetic model of development of acute viral infection in the human body. Critical conditions, control mechanisms, “thermoheliox”

• DOI: 10.1007/s11172-020-2886-4
• Publication Date: 2020-07-20T11:02:46Z
• Authors: S. D. Varfolomeev; A. A. Panin; V. I. Bykov; S. B. Tsybenova; L. V. Shogenova; A. G. Chuchalin
• Keywords: 03 medical and health sciences; 0302 clinical medicine; Full Articles; 3. Good health

A kinetic model of the development of acute viral infection is proposed and the dynamic behavior of key variables, including the concentrations of viral particles, infected cells, and pathogenic microorganisms, is described. The change in the hydrogen ion concentration in the lungs and pH dependence of the activity of carbonic anhydrase, a key respiration enzyme, are critical factors. An acute bifurcation transition determining either the life or collapse of the system is demonstrated. The transition is associated with exponential increase in the concentrations of participants in the process and with functioning of the key enzyme, carbonic anhydrase. A physicochemical interpretation is given for the therapeutic effect of temperature rise and potential therapeutic effect of "thermoheliox", that is, breathing by heated helium-oxygen mixture.