Facile synthesis of 6-organyl-4-(trifluoromethyl)pyridin-2(1H)-ones and their polyfluoroalkyl-containing analogs

• DOI: 10.1007/s11172-022-3579-y
• Publication Date: 2022-09-23T04:03:56Z
• Authors: S. O. Kushch; M. V. Goryaeva; Ya. V. Burgart; G. A. Triandafilova; K. O. Malysheva; O. P. Krasnykh; N. A. Gerasimova; N. P. Evstigneeva; V. I. Saloutin
• Keywords: Full Articles; 01 natural sciences; 0104 chemical sciences

The three-component cyclization of 3-polyfluoroalkyl-3-oxopropanoates and methyl ketones with ammonium acetate affords 6-organyl-4-(polyfluoroalkyl)pyridin-2(1H)-ones (organyl is alkyl, aryl, or hetaryl). The synthesized pyridones were evaluated for antifungal, antibacterial, and analgesic activity.