Low on-clopidogrel ADP- and TRAP-6-induced platelet aggregation in patients with atrial fibrillation undergoing percutaneous coronary intervention: an observational pilot study

• DOI: 10.1007/s11239-023-02937-0
• Publication Date: 2024-02-12T21:02:46Z
• Authors: Diona Gjermeni; Viktoria Anfang; Hannah Vetter; Sofia Szabó; David Hesselbarth; Nadine Gauchel; Patrick M. Siegel; Klaus Kaier; Alexander Kille; Kilian Franke; Stefan Leggewie; Dietmar Trenk; Daniel Duerschmied; Christoph Bode; Dirk Westermann; Christoph B. Olivier
• Keywords: Interquartile range; Stroke

Abstract High on-clopidogrel platelet reactivity (HPR) associates with ischemic risk in patients after percutaneous intervention (PCI). This study aimed to evaluate the association of HPR as assessed by multiple electrode aggregometry (MEA) ischemic, thromboembolic, and bleeding atrial fibrillation (AF) undergoing PCI. Patients AF an indication for oral anticoagulation (OAC) were included this prospective cohort on day 1–3 Platelet aggregation [U] was analyzed MEA. low (LPR) defined ADP-induced ≥ 46 U ≤ 18 U, respectively. TRAP-6-induced reference 94–156 U. The primary outcome time all-cause death, myocardial infarction, or stroke at 6 months. secondary non-major clinically relevant bleedings major bleedings. 159 enrolled between May 2020 2021. median age 78 years (interquartile range 72–82) 111 (70%) male. Median ADP- TRAP-induced 12 (6–17) 49 (35–68) 147 (93%) had a overall aggregability. detected 2 (1%) 125 (79%) LPR. did not significantly associate (r = 0.081, p 0.309) but correlated inversely − 0.201, 0.011). status MEA among PCI rare aggregability low. Conventional cut-off values might be inappropriate these patients. helpful identify bleeding.