Mesangial proliferative glomerulonephritis in familial Mediterranean fever patient with E148Q mutation: the first case report

• DOI: 10.1007/s11255-012-0124-1
• Publication Date: 2012-01-19T08:33:13Z
• Authors: Eray Eroglu; Ismail Kocyigit; Ozturk Ates; Aydin Unal; Murat Hayri Sipah...; Hulya Akgun; Bulent Tokgoz; Oktay Oymak
• Keywords: Young Adult; 03 medical and health sciences; Glomerulonephritis; 0302 clinical medicine; Mutation; Humans; Female; Familial Mediterranean Fever; Glomerular Mesangium; 3. Good health

Familial Mediterranean fever (FMF) is an autosomal recessive hereditary disease characterized by recurrent attacks of fever, usually accompanied by sterile polyserositis. Although amyloidosis is the most common renal involvement, non-amyloid renal lesions, such as glomerulonephritis, have been described in patients with FMF. In this report, we present the first case of an FMF patient with heterozygous mutation of E148Q, mesangial proliferative glomerulonephritis, and no amyloidosis. While the association of mutation E148Q with renal involvement is still obscure, colchicine treatment is useful in mesangial proliferative glomerulonephritis with FMF.