Antiviral activity of canine interferon lambda 3 expressed using a recombinant adenovirus against canine coronavirus, canine parvovirus, and canine distemper virus

• DOI: 10.1007/s11259-022-10000-1
• Publication Date: 2022-09-26T11:03:35Z
• Authors: Dong-Hwi Kim; Sang-Hoon Han; Hyeon-Jeong Go; Da-Yoon Kim; Jae-Hyeong Kim; Joong-Bok Lee; Seung-Yong Park; Chang-Seon Song; Sang-Won Lee; In-Soo Choi
• Keywords: Canine distemper; Canine parvovirus; Coronavirus

Abstract Canine coronavirus (CCoV), canine parvovirus (CPV), and canine distemper virus (CDV) are highly contagious canine pathogens; dogs with these diseases are difficult to treat. In a previous study, we developed a recombinant adenovirus expressing canine interferon lambda 3 (Ad-caIFNλ3) in canine epithelial cells. This study aimed at investigating the antiviral activity of Ad-caIFNλ3 against CCoV, CPV, and CDV in two canine cell lines, A72 and MDCK. Ad-caIFNλ3 transduction suppressed replication of these viruses without cytotoxicity. These results suggested that Ad-caIFNλ3 may be a therapeutic candidate for canine viral diseases.