Emergency vaccination of cattle against lumpy skin disease: Evaluation of safety, efficacy, and potency of MEVAC® LSD vaccine containing Neethling strain

• DOI: 10.1007/s11259-022-10037-2
• Publication Date: 2022-12-03T03:03:12Z
• Authors: Abdel-Hamid Bazid; Momtaz Wasfy; Mohamed Fawzy; Mohamed Nayel; Mohamed Abdelmegeid; Randa Y. Thabet; Hui Sian Yong; Magdy M. El-Sayed; Asmaa Magouz; Yassien Badr
• Keywords: Strain (injury)

Lumpy skin disease (LSD) is an emerging of cattle causing significantly high economic losses. Control LSD depends on the use homologous attenuated virus strains isolated originally from South Africa (the Neethling strain). The belongs to genus Capripoxvirus, which includes sheep pox and goat virus. present study was conducted evaluate safety efficacy a new live vaccine produced by Middle East for Vaccines (MEVAC®) based strain. Tests were performed both in Egypt Vietnam. Safety evaluated inoculation five with 10 times recommended dose observation animals 14 days. Immunogenicity tested at different periods post-vaccination (PV) receiving doses using ELISA neutralization test. Five cows used determine protection index (PI) non-vaccinated control included. Three calves challenged intradermal wild (5 × 105 TCID50) 28 days PV. Field or mass vaccination experiments Vietnam during national campaigns summer 2021 4301 vaccinated closely monitored after vaccination. In field, around 2% (80/4301) showed hyper-reactivity, 0.6% (24/4301) small swellings that disappeared within few hours Abortion recorded three (0.3% 3/867). Challenged resistant clinical PI value 3.5 log10. Meanwhile, antibody levels determined inconsistent among laboratories period. Overall, findings point safe effective vaccine.