Deltamethrin-induced nuclear erythrocyte alteration and damage to the gills and liver of Colossoma macropomum

• DOI: 10.1007/s11356-018-1622-1
• Publication Date: 2018-03-20T00:30:17Z
• Authors: Fernanda dos Sant...; Natalino da Costa...; Rudã Fernandes Br...; Juliana Oliveira ...; Márcia Valéria Si...; Fabrício Tavares ...; José Guedes de Se...; Paulo César Falan...; Alexandre Nizio M...; Rodrigo Yudi Fuji...
• Keywords: Cell Nucleus; Gills; 2. Zero hunger; 0301 basic medicine; 0303 health sciences; Erythrocytes; Fishes; 3. Good health; Lethal Dose 50; 03 medical and health sciences; Liver; Nitriles; Pyrethrins; Toxicity Tests, Acute; Animals; Water Pollutants, Chemical; DNA Damage

Deltamethrin is one of the most commonly used pyrethroids in the world, and it has a high toxic potential, mainly on aquatic organism. Thus, the purpose of this study was to evaluate LC50 values of deltamethrin on tambaqui (Colossoma macropomum) fingerlings and to investigate genotoxic effects and histopathological responses. Fish were exposed to different concentrations of deltamethrin (0, 6.16 × 10-3; 6.44 × 10-2; 1.34 × 10-1, and 1.93 × 10-1 mg L-1) for 96 h. In addition, a genotoxicity analysis was carried out on peripheral blood erythrocytes and histopathological changes were classified by the severity degree of damage and organ functioning. The 96 h LC50 value for tambaqui was estimated at 5.56 × 10-2 mg L-1 using a static test system. Nuclear abnormalities in exposed fish included micronuclei, blebbed, notched, 8-shaped, and binucleated nuclei forms. Deltamethrin significantly induced a notched nucleus compared to other abnormalities. A histopathological examination showed hepatic lesions and gill damage. Deltamethrin was found to be highly toxic; it induced genotoxicity and caused liver and gill inflammation in tambaqui.