The effect of repeated cadmium oral exposure on the level of sex hormones, estrous cyclicity, and endometrium morphometry in female rats

• DOI: 10.1007/s11356-018-2821-5
• Publication Date: 2018-07-31T15:51:23Z
• Authors: Marzenna Nasiadek; Marian Danilewicz; Krystyna Sitarek; Ewa Świątkowska; Adam Daragó; Joanna Stragierowicz; Anna Kilanowicz
• Keywords: Endocrine disruptor

Cadmium (Cd) is regarded as a potential endocrine disruptor. However, the exact mechanism by which this metal may interfere with reproductive system has not yet been elucidated. The present study aimed to investigate effect of subacute Cd oral administration at daily doses 0.09, 1.8, and 4.5 mgCd/kg b.w. impact on sex hormones (estradiol (E2) progesterone (P)) in plasma uterus, well estrous cyclicity histopathological changes uterine ovary female rats after terminating exposure prolonged observation period (3 months). Moreover, bioaccumulation brain tissue was analyzed. revealed that induced levels steroid hormones: decrease E2 increase P highest dose Cd. Probably, for first time, it evidenced circulation hormone disturbances Cd-exposed caused irregular cycle, persisting 3 months termination; no alterations these were noted. did induce estradiol-like hyperplasia endometrium, but resulted endometrial edema irrespective dose, damage ovaries dose. In summary, lead long-term system.