DEHP mediates drug resistance by metabolic reprogramming in colorectal cancer cells

• DOI: 10.1007/s11356-022-25110-1
• Publication Date: 2023-02-07T11:23:08Z
• Authors: Yue Wu; Ruijie Lu; Yujie Lin; Jinjin Wang; Zijian Lou; Xiaochun Zheng; Ling Zhang; Ruolang Pan; Gang Lu; Qingxia Fang
• Keywords: Reprogramming

Long-term exposure to diethylhexyl phthalate (DEHP), an endocrine-disrupting chemical (EDCs) and plasticizer widely used in consumer products, has been reported be significantly positively correlated with increased risks of different human diseases, including various cancers, while the potential effect DEHP on colorectal cancer progression was little studied. In present study, we showed that could trigger metabolic reprogramming cells, promote cell growth decrease fluorouracil (5-FU) sensitivity. Mechanistic studies indicated reduce glycolysis activity increase oxidative phosphorylation (OXPHOS) SW620 cells. addition, vivo experiments promoted tumorigenic decreased survival time mice. Collectively, our findings suggest may a potent risk factor for development.