Serum triiodothyronine levels and inflammatory cytokine production capacity

• DOI: 10.1007/s11357-011-9220-x
• Publication Date: 2011-02-24T01:06:05Z
• Authors: Maarten P. Rozing; Rudi G. J. Westen...; Andrea B. Maier; Carolien A. Wijsman; Marijke Frölich; Anton J. M. de Craen; Diana van Heemst
• Keywords: Proinflammatory cytokine; Ex vivo

Increasing evidence suggests that pro-inflammatory cytokines are at play in lowering peripheral thyroid hormone levels during critical illness. Conversely, hormones have been suggested to enhance production of inflammatory cytokines. In view these considerations, we hypothesized a mutual association between triiodothyronine and Therefore evaluated the relation both circulating induced markers serum function parameters Leiden 85-plus Study. We found higher were associated with lower free triiodothyronine. turn, related capacity after stimulation lipopolysaccharide. By combining vivo ex data, able demonstrate for first time existence potential feedback mechanism immune capacity. conclude maintenance normal might be important preserved response elderly human populations.