Dietary intake of eicosapentaenoic and docosahexaenoic acids is linked to gray matter volume and cognitive function in elderly

• DOI: 10.1007/s11357-012-9453-3
• Publication Date: 2012-07-12T06:34:10Z
• Authors: Olga E. Titova; Per Sjögren; Samantha J. Brooks; Joel Kullberg; Erika Ax; Lena Kilander; Ulf Riserus; Tommy Cederholm; Elna-Marie Larsson; Lars Johansson; Håkan Ahlström; Lars Lind; Helgi B. Schiöth; Christian Benedict
• Keywords: Cognitive Decline

In the present study, we tested whether elderly with a high dietary intake of eicosapentaenoic acid (EPA) and docosahexaenoic (DHA) would have higher cognitive test scores greater brain volume than those low these fatty acids. Data were obtained from Prospective Investigation Vasculature in Uppsala Seniors (PIVUS) cohort. The EPA DHA was determined by 7-day food protocol 252 cognitively healthy (122 females) at age 70 years. At 75, participants' global function examined, their volumes measured magnetic resonance imaging (MRI). Three different multivariate linear regression models applied to our hypothesis: model A (adjusted for gender age), B (additionally controlled lifestyle factors, e.g., education), C (further cardiometabolic systolic blood pressure). We found that self-reported years positively associated gray matter (P < 0.05, except C) increased performance score 0.05). However, no significant associations observed between white matter, total volume, regional respectively. Further, effects when examining impaired (n = 27) as separate analyses. These cross-sectional findings suggest may be linked improved health late life but must confirmed patient studies.