Antioxidant and antiglycating activities of Salvia sahendica and its protective effect against oxidative stress in neuron-like PC12 cells

• DOI: 10.1007/s11418-011-0519-9
• Publication Date: 2011-03-17T17:26:25Z
• Authors: Fatemeh Shaerzadeh; Abolhassan Ahmadiani; Mohammad Ali Esma...; Niloufar Ansari; Sareh Asadi; Solaleh Khoramian...; Ali Sonboli; Mina Ghahremanzam...; Fariba Khodagholi
• Keywords: 0301 basic medicine; Cell Death; Plant Extracts; Superoxide Dismutase; Hydrogen Peroxide; Catalase; PC12 Cells; Antioxidants; Rats; 3. Good health; Oxidative Stress; 03 medical and health sciences; Animals; Lipid Peroxidation; Salvia; Chromatography, High Pressure Liquid

Increased oxidative stress is widely accepted to be a factor in the development and progression of Alzheimer's disease (AD). Here we introduced Salvia sahendica as a protective agent in differentiated PC12 cells, which are commonly considered to be a reliable model of neuronal cells. Our results demonstrated that S. sahendica has antioxidant and antiglycating properties in in vitro system and these properties are expanded into H(2)O(2)-induced model. S. sahendica inhibited H(2)O(2)-induced cell death in PC12 cells. We further showed that this plant exerts its protective effect by increasing superoxide dismutase and catalase levels, reducing lipid peroxidation and upregulating hemoxygenase-1 and glutamylcysteine synthetase proteins. This study raises the possibility of developing S. sahendica as a potential neuroprotective agent.