Ceramicines J–L, new limonoids from Chisocheton ceramicus

• DOI: 10.1007/s11418-011-0616-9
• Publication Date: 2011-12-12T11:41:48Z
• Authors: Chin Piow Wong; Misae Shimada; Alfarius Eko Nugroho; Yusuke Hirasawa; Toshio Kaneda; A. Hamid A. Hadi; Shirota Osamu; Hiroshi Morita
• Keywords: Limonins; Magnetic Resonance Spectroscopy; Molecular Structure; Plant Bark; Humans; HL-60 Cells; Meliaceae; 01 natural sciences; Cell Proliferation; 0104 chemical sciences

Three new limonoids, ceramicines J (1), K (2), and L (3), were isolated from the hexane layer of Chisocheton ceramicus bark extract. Their structures were elucidated from 1D and 2D NMR data. Ceramicines J-L (1-3) exhibited dose-dependent moderate cytotoxicity against the HL-60 cell line.