Terpenoids from Vitex trifolia and their anti-inflammatory activities

• DOI: 10.1007/s11418-018-1178-x
• Publication Date: 2018-02-10T00:21:33Z
• Authors: Fengyan Bao; Ruotian Tang; Li Cheng; Cuiyun Zhang; Chongyue Qiu; Ting Yuan; Lihan Zhu; Hua Li; Lixia Chen
• Keywords: Vitex; Plant Extracts; Terpenes; Anti-Inflammatory Agents; 01 natural sciences; 3. Good health; 0104 chemical sciences

A new diterpenoid glucoside, (3S,5S,6S,8R,9R,10S)-3,6,9-trihydroxy-13(14)-labdean-16,15-olide 3-O-β-D-glucopyranoside (1), and a new iridoid glucoside, (1S, 5S,6R,9R)-10-O-p-hydroxybenzoyl-5,6β-dihydroxy iridoid 1-O-β-D-glucopyranoside (2), along with six known compounds (3-8) were isolated from Vitex trifolia L.. Their structures were elucidated by extensive spectroscopic analysis. All these isolated compounds were evaluated for their inhibitory effects on nitric oxide production in LPS-induced RAW 264.7 macrophages. Compounds 2, 4, 5, and 7 showed moderate inhibitory activities with IC50 values of 90.05, 88.51, 87.26, and 76.06 μM, respectively.