Leucophyllinines A and B, bisindole alkaloids from Leuconotis eugeniifolia

• DOI: 10.1007/s11418-019-01297-5
• Publication Date: 2019-03-25T13:02:39Z
• Authors: Yiming Tang; Alfarius Eko Nugroho; Yusuke Hirasawa; Takahiro Tougan; Toshihiro Horii; A. Hamid A. Hadi; Hiroshi Morita
• Keywords: 0301 basic medicine; Molecular Structure; Plasmodium falciparum; Q Science (General); R Medicine; QD Chemistry; Indole Alkaloids; 3. Good health; Apocynaceae; Antimalarials; 03 medical and health sciences; Plant Bark; Humans

Two new bisindole alkaloids, leucophyllinines A (1) and B (2) consisting of eburnane and quebrachamine-type skeletons were isolated from the bark of Leuconotis eugeniifolia, and their structures were elucidated on the basis of spectroscopic data. Leucophyllinines A and B showed antiplasmodial activities against Plasmodium falciparum 3D7.