New sesquiterpenes from the soft coral Litophyton arboreum

• DOI: 10.1007/s11418-024-01843-w
• Publication Date: 2024-10-22T21:01:54Z
• Authors: Amany Hamouda Mah...; Sabry A. H. Zidan; Mamdouh Nabil Samy; Abdallah Alian; Mahmoud A. A. Ibr...; Mostafa Ahmed Fouad; Mohamed Salah Kamel; Katsuyoshi Matsunami

Abstract Two new sesquiterpenes; 8α,11-dihydroxy-β-cyperon ( 2 ), and 5- epi -7α-hydroxy-( +)-oplopanone 3 were isolated from the soft coral Litophyton arboreum, together with nine known ones, including five 11-hydroxy-8-oxo-β-cyperon 1 alismoxide 4 5β,8β-epidioxy-11-hydroxy-6-eudesmene 5 chabrolidione B 6 7-oxo-tri-nor-eudesm-5-en-4β-ol 7 two sterols; 7β-acetoxy-24-methyl-cholesta-5,24(28)-diene-3β,19-diol 8 nebrosteroid M 9 glycerol derivatives; chimyl alcohol 10 ) batyl 11 ). The structures of compounds characterized using spectroscopic techniques, predominately HR-ESI–MS, 1D, 2D-NMR, ECD analyses. Compounds – evaluated for their cytotoxic activity against three human cancer-cell lines (A549, MCF-7 HepG2), anti-leishmanial potential causal parasite, Leishmania major. , exhibited potent A549 cell line (IC 50 = 17.0 ± 2.5, 13.5 2.1, 16.5 1.3 μg/ml, respectively) as compared standard antitumor agent etoposide 28.4 4.5 μg/ml). In addition, compound remarkable 24.7 2.1 μg/ml: 22.2 4.2 μg/mL etoposide). Graphical abstract