An efficient three-component domino synthesis of difluoromethyl-containing 1,4-dihydropyridines under solvent and catalyst free conditions

• DOI: 10.1007/s11426-010-4005-0
• Publication Date: 2010-07-31T19:49:11Z
• Authors: Hui Li; JinLong Yu; Song Cao; Li Shen; MingXi Wu; JianHang Cheng; XuHong Qian
• Keywords: 01 natural sciences; 0104 chemical sciences

The difluoromethyl-containing Hantzsch 1,4-dihydropyridines were synthesized in good yields by a one-pot cyclocondensation of ethyl difluoroacetoacetate (EDFAA), a variety of aromatic aldehydes and ammonium acetate under solvent and catalyst free conditions. The comparison of reaction conditions and products was made among the different 1,3-carbonyl substrates (ethyl acetoacetate, ethyl difluoroacetoacetate and ethyl trifluoroacetoacetate) for the Hantzsch reaction.