Visible light promoted synthesis of N-aroylsulfoximines by oxidative C-H acylation of NH-sulfoximines

• DOI: 10.1007/s11426-019-9499-5
• Publication Date: 2019-07-12T07:04:52Z
• Authors: Wenlong Jiang; Youming Huang; Lihong Zhou; Qingle Zeng
• Keywords: Chirality; Visible spectrum; Functional group

The visible light-promoted synthesis of N -aroylsulfoximines has been accomplished via an oxidative dehydrogenative coupling at room temperature under air without the addition of a photosensitizer, metal catalyst, or base. This process exhibits good functional group tolerance, allows facile isolation and purification, and affords N -aroylsulfoximines with high efficiency. The efficiency of the newly developed protocol is described in detail with 27 examples with yields ranging from 80% to 96%. Furthermore, the chirality of the NH -sulfoximine is completely maintained in the desired N -aroylsulfoximine product (>99% ee).