Ingestion of Lactobacillus strain reduces anxiety and improves cognitive function in the hyperammonemia rat

• DOI: 10.1007/s11427-014-4615-4
• Publication Date: 2014-02-19T09:21:07Z
• Authors: Jia Luo; Tao Wang; Shan Liang; Xu Hu; Wei Li; Feng Jin
• Keywords: Elevated plus maze; Hyperammonemia

Evidence suggests that the hyperammonemia (HA)-induced neuroinflammation and alterations in serotonin (5-HT) system may contribute to cognitive decline anxiety disorder during hepatic encephalopathy (HE). Probiotics maintain immune homeostasis regulate 5-HT be potential treatment for HA-mediated neurological disorders HE. In this study, we tested efficacy of probiotic Lactobacillus helveticus strain NS8 preventing anxiety-like behavior HA rats. Chronic was induced by intraperitoneal injection ammonium acetate four weeks male Sprague-Dawley rats were then given (109 CFU mL−1) drinking water as a daily supplementation. The Morris maze task assessed function, elevated plus test evaluated behavior. Neuroinflammation measuring inflammatory markers: inducible nitric oxide synthase, prostaglandin E2, interleukin-1 β brain. activity its metabolite, 5-HIAA, precursor, tryptophan. Probiotic significantly reduced level markers, decreased metabolism, restored function improved These results indicate L. is beneficial