PITPNC1 promotes the thermogenesis of brown adipose tissue under acute cold exposure

• DOI: 10.1007/s11427-022-2157-y
• Publication Date: 2022-09-27T05:02:51Z
• Authors: Guoqing Tang; Chengxin Ma; Liangkui Li; Shaoyan Zhang; Fengsheng Li; Jin Wu; Yesheng Yin; Qing Zhu; Yan Liang; Ru Wang; He Huang; Tong-Jin Zhao; Hongyuan Yang; Peng Li; Feng-Jung Chen
• Keywords: Homeothermy; Thermogenin

Abstract Brown adipose tissue (BAT) plays an essential role in non-shivering thermogenesis. The phosphatidylinositol transfer protein, cytoplasmic 1 (PITPNC1) is identified as a lipid transporter that reciprocally transfers phospholipids between intracellular membrane structures. However, the physiological significance of PITPNC1 and its regulatory mechanism remain unclear. Here, we demonstrate key player thermogenesis BAT. While Pitpnc1 −/− mice do not differ with wildtype body weight insulin sensitivity on either chow or high-fat diet, they develop hypothermia when subjected to acute cold exposure at 4°C. brown adipocytes exhibit defective β-oxidation abnormal thermogenesis-related metabolism pathways mitochondria. deficiency mobilization might be result excessive accumulation phosphatidylcholine reduction phosphatidic acid. Our findings have uncovered significant roles mitochondrial phospholipid homeostasis BAT