Face activated neurodynamic cortical networks

• DOI: 10.1007/s11517-011-0740-4
• Publication Date: 2011-02-08T16:42:29Z
• Authors: Ana Susac; Risto J. Ilmoniemi; Doug Ranken; Selma Supek
• Keywords: ta113; 0301 basic medicine; ta112; magnetoencephalography; spatio-temporal source localization; face processing; oddball paradigm; fusiform face gyrus; Brain Mapping; ta114; ta111; ta1182; Magnetoencephalography; 03 medical and health sciences; Pattern Recognition, Visual; Face; Neural Pathways; Reaction Time; Feasibility Studies; Humans; Nerve Net; ta116; Photic Stimulation

Previous neuroimaging studies have shown that complex visual stimuli, such as faces, activate multiple brain regions, yet little is known on the dynamics and complexity of the activated cortical networks during the entire measurable evoked response. In this study, we used simulated and face-evoked empirical MEG data from an oddball study to investigate the feasibility of accurate, efficient, and reliable spatio-temporal tracking of cortical pathways over prolonged time intervals. We applied a data-driven, semiautomated approach to spatio-temporal source localization with no prior assumptions on active cortical regions to explore non-invasively face-processing dynamics and their modulation by task. Simulations demonstrated that the use of multi-start downhill simplex and data-driven selections of time intervals submitted to the Calibrated Start Spatio-Temporal (CSST) algorithm resulted in improved accuracy of the source localization and the estimation of the onset of their activity. Locations and dynamics of the identified sources indicated a distributed cortical network involved in face processing whose complexity was task dependent. This MEG study provided the first non-invasive demonstration, agreeing with intracranial recordings, of an early onset of the activity in the fusiform face gyrus (FFG), and that frontal activation preceded parietal for responses elicited by target faces.