Compartmental Model Suggests Importance of Innate Immune Response to COVID-19 Infection in Rhesus Macaques

• DOI: 10.1007/s11538-021-00909-0
• Publication Date: 2021-05-26T08:02:53Z
• Authors: Ericka Mochan; T. J. Sego; Lauren Gaona; Emmaline Rial; G. Bard Ermentrout
• Keywords: Pandemic; Host response

The pandemic outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has quickly spread worldwide, creating a serious health crisis. virus is primarily associated with flu-like symptoms but can also lead to pathologies and death. We here present an ordinary differential equation model the intrahost immune response SARS-CoV-2 infection, fitted experimental data gleaned from rhesus macaques. calibrated nonlethal replicate behavior various lethal scenarios as well. evaluate sensitivity biologically relevant parameters governing strength efficacy response. simulate effect both anti-inflammatory antiviral drugs on host demonstrate ability lessen severity formerly infection addition appropriately drug. Our emphasizes importance tight control innate for survival viral clearance.