Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs): a radiomic model to predict tumor grade

• DOI: 10.1007/s11547-022-01529-x
• Publication Date: 2022-08-02T04:02:54Z
• Authors: Giuditta Chiti; Giulia Grazzini; Federica Flammia; Benedetta Matteuzzi; Paolo Tortoli; Silvia Bettarini; Elisa Pasqualini; Vincenza Granata; Simone Busoni; Luca Messserini; Silvia Pradella; Daniela Massi; Vittorio Miele
• Keywords: Pancreatic Neoplasms; Neuroendocrine Tumors; 03 medical and health sciences; 0302 clinical medicine; Humans; Tomography, X-Ray Computed; Gastrointestinal Neoplasms; Retrospective Studies; 3. Good health

The aim of this single-center retrospective study is to assess whether contrast-enhanced computed tomography (CECT) radiomics analysis is predictive of gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) grade based on the 2019 World Health Organization (WHO) classification and to establish a tumor grade (G) prediction model.Preoperative CECT images of 78 patients with GEP-NENs were retrospectively reviewed and divided in two groups (G1-G2 in class 0, G3-NEC in class 1). A total of 107 radiomics features were extracted from each neoplasm ROI in CT arterial and venous phases acquisitions with 3DSlicer. Mann-Whitney test and LASSO regression method were performed in R for feature selection and feature reduction, in order to build the radiomic-based predictive model. The model was developed for a training cohort (75% of the total) and validated on the independent validation cohort (25%). ROC curves and AUC values were generated on training and validation cohorts.40 and 24 features, for arterial phase and venous phase, respectively, were found to be significant in class distinction. From the LASSO regression 3 and 2 features, for arterial phase and venous phase, respectively, were identified as suitable for groups classification and used to build the tumor grade radiomic-based prediction model. The prediction of the arterial model resulted in AUC values of 0.84 (95% CI 0.72-0.97) and 0.82 (95% CI 0.62-1) for the training cohort and validation cohort, respectively, while the prediction of the venous model yielded AUC values of 0.7877 (95% CI 0.6416-0.9338) and 0.6813 (95% CI 0.3933-0.9693) for the training cohort and validation cohort, respectively.CT-radiomics analysis may aid in differentiating the histological grade for GEP-NENs.