Study rationale and design of the PEOPLHE trial

• DOI: 10.1007/s11547-024-01764-4
• Publication Date: 2024-02-06T14:02:26Z
• Authors: Gianluca Milanese; Mario Silva; Roberta Eufrasia ...; Elisa Iezzi; Chandra Bortolotto; Letizia Antonella...; Adele Valentini; Linda Reali; Olivia Maria Bott...; Adriana Ilardi; Antonio Basile; Stefano Palmucci; Lorenzo Preda; Nicola Sverzellati; ; Lorenzo Aliotta; Sebastiano Barbarino; Santo Borzì; Virginia Casotto; Marco Catalano; Domenico Maria Ca...; Mariangela Clemenza; Martina Contino; Luca Crimi; Bruno Curia; Pasquale Favia; Vita Ida Gallone; Giulia Guicciardi; Giuliana La Rosa; Ludovica Leo; Rebecca Mura; Antonella Priore; Lidia Ruongo; Carlotta Scavone; Carlotta Zilioli
• Keywords: 03 medical and health sciences; 0302 clinical medicine; Primary and secondary prevention; Lung cancer screening; Chest Radiology; 616; 610; 613; Lung cancer; Lung-RADS; Low-dose computed tomography

Abstract Purpose Lung cancer screening (LCS) by low-dose computed tomography (LDCT) demonstrated a 20–40% reduction in lung mortality. National stakeholders and international scientific societies are increasingly endorsing LCS programs, but translating their benefits into practice is rather challenging. The “Model for Optimized Implementation of Early Cancer Detection: Prospective Evaluation Of Preventive HEalth” (PEOPLHE) an Italian multicentric program aiming at testing feasibility implementation within the national healthcare system. PEOPLHE intended to assess (i) strategies optimize workflow, (ii) radiological quality assurance, (iii) need dedicated resources, including smoking cessation facilities. Methods aims recruit 1.500 high-risk individuals across three tertiary general hospitals different regions that provide comprehensive services large populations explore geographic, demographic, socioeconomic diversities. Screening LDCT will target current or former (quitting < 10 years) smokers (> 15 cigarettes/day > 25 years, 30 aged 50–75 years. nodules be volumetric measured classified modified Lung-RADS 1.1 Current offered support. Conclusion information on enrollment interventions; administrative, organizational, needs performing state-of-the-art LCS; collateral incidental findings (both pulmonary extrapulmonary), contributing systems.