Clinicopathological Feature and Surgical Outcome of Choledochal Cyst in Different Age Groups: The Implication of Surgical Timing

• DOI: 10.1007/s11605-008-0593-9
• Publication Date: 2008-08-01T14:19:11Z
• Authors: Ming-Shian Tsai; Wen-Hsi Lin; Wen-Ming Hsu; Hong-Shiee Lai; Po-Huang Lee; Wei-Jao Chen
• Keywords: Adult; Male; Chi-Square Distribution; Adolescent; Age Factors; Infant, Newborn; Infant; Middle Aged; Statistics, Nonparametric; 3. Good health; 03 medical and health sciences; Postoperative Complications; Treatment Outcome; 0302 clinical medicine; Child, Preschool; Choledochal Cyst; Humans; Female; Child; Retrospective Studies

Surgical resection of choledochal cysts (CC) has become standard treatment. However, surgery is not universally recommended in early infancy and/or asymptomatic patients. In order to investigate the optimal timing of CC excision, we analyzed clinicopathological data and surgical results from different age groups.This retrospective review included 107 patients (77 females, 30 males) who underwent CC resection at the National Taiwan University Hospital between January 1988 and December 2005. Patient demographic, clinical, and surgical data were collected and analyzed.The patients were divided into three groups according to age at the time of surgery: <1 year old (group I, n = 26), 1-16 years old (group II, n = 48), and >16 years old (group III, n = 33). About two thirds of the patients in group I had jaundice, while abdominal pain related to inflammation was the commonest symptom in groups II and III. Group I suffered significantly fewer surgical complications and less severe liver fibrosis than groups II or III.CC surgery in infancy and in asymptomatic patients is safe and may prevent the complications of this condition. The results support a recommendation for early excision.