Anacardic acid (6-pentadecylsalicylic acid) induces apoptosis of prostate cancer cells through inhibition of androgen receptor and activation of p53 signaling

• DOI: 10.1007/s11670-012-0264-y
• Publication Date: 2013-03-21T03:53:37Z
• Authors: Jing Tan; Binghai Chen; Leye He; Yuxin Tang; Zhiqiang Jiang; Guangmin Yin; Jinrong Wang; Xianzhen Jiang
• Keywords: 0301 basic medicine; 03 medical and health sciences; 3. Good health

Anacardic acid (AA) is a mixture of 2-hydroxy-6-alkylbenzoic homologs. It widely regarded as non-specific histone acetyltransferase inhibitor p300. The effects and the mechanisms AA in LNCaP cells (prostate cancer cells) remain unknown. To investigate effect on cells, we had carried out several experiments found that inhibits cell proliferation, induces G1/S cycle arrest apoptosis cell. via which acts may be due to following aspects. First, can regulate p300 transcription protein level except for its regulating function through post-translational modification cells. Second, activate p53 increasing phosphorylation Ser15 selectively p21 (target genes p53). Third, down-regulates androgen receptor (AR) supressing Our study suggests has multiple anti-tumor activities warrants further investigation.