A Novel Approach to Molecular Recognition Surface of Magnetic Nanoparticles Based on Host–Guest Effect

• DOI: 10.1007/s11671-009-9314-x
• Publication Date: 2009-04-22T05:28:07Z
• Authors: Yuanpeng Wu; Fang Zuo; Zhaohui Zheng; Xiaobin Ding; Yuxing Peng
• Keywords: Thermogravimetric analysis; Nanochemistry

A novel route has been developed to prepared beta-cyclodextrin (beta-CD) functionalized magnetic nanoparticles (MNPs). The MNPs were first modified with monotosyl-poly(ethylene glycol) (PEG) silane and then tosyl units displaced by amino-beta-CD through the nucleophilic substitution reaction. monotosyl-PEG was synthesized modifying a PEG diol form corresponding monotosyl-PEG, followed reaction 3-isocyanatopropyltriethoxysilane (IPTS). success of synthesis confirmed (1)H NMR Fourier transform infrared (FTIR) spectroscopy. analysis FTIR spectroscopy X-ray photoelectron (XPS) immobilization beta-CD onto MNPs. Transmission electron microscopy (TEM) indicated that mostly present as individual nonclustered in water. number molecules immobilized on each MNP about 240 according thermogravimetric (TGA) results. as-prepared used detect dopamine assistance magnet.