Relationship Between Obesity and Diabetes in a US Adult Population: Findings from the National Health and Nutrition Examination Survey, 1999–2006
Adult
Male
and promotion of well-being
Endocrinology, Diabetes and Metabolism
Clinical Sciences
Comorbidity
Severity of Illness Index
Body Mass Index
03 medical and health sciences
0302 clinical medicine
Diabetes Mellitus
Humans
Obesity
Morbid
Metabolic and endocrine
Nutrition
Glycated Hemoglobin
2. Zero hunger
Nutrition and Dietetics
C-Peptide
Prevention
Diabetes
National Health and Nutrition Examination Survey
Middle Aged
Prevention of disease and conditions
Nutrition Surveys
16. Peace & justice
United States
Obesity, Morbid
3. Good health
Cross-Sectional Studies
Diabetes Mellitus, Type 2
Public Health and Health Services
3.1 Primary prevention interventions to modify behaviours or promote wellbeing
Surgery
Female
HbA1c levels
Type 2
Basic Science Research
DOI:
10.1007/s11695-010-0335-4
Publication Date:
2010-12-02T16:06:14Z
AUTHORS (4)
ABSTRACT
Obesity is one of the most important modifiable risk factors for the prevention of type 2 diabetes. The aim of this study was to examine the prevalence of diabetes with increasing severity of obesity and the distribution of HbA1c levels in diabetics participating in the latest National Health and Nutrition Examination Survey (NHANES).Data from a representative sample of adults with diabetes participating in the NHANES between 1999 and 2006 were reviewed. The prevalence of diabetes and levels of fasting glucose, insulin, c-peptide, and HbA1c were examined across different weight classes with normal weight, overweight, and obesity classes 1, 2, and 3 were defined as body mass index (BMI) of <25.0, 25.0-29.9, 30.0-34.9, 35.0-39.9, and equal to 40.0, respectively. The distribution of HbA1c levels among adults with diabetes was also examined.There were 2,894 adults with diabetes (13.6%) among the 21,205 surveyed participants. Among the adults with diabetes, the mean age was 59 years, the mean fasting glucose was 155 ± 2 mg/dl, and the mean HbA1c was 7.2%; 80.3% of diabetics were considered overweight (BMI ≥ 25) and 49.1% of diabetics were considered obese (BMI ≥ 30). The prevalence of adults with diabetes increased with increasing weight classes, from 8% for normal weight individuals to 43% for individuals with obesity class 3; the distribution of HbA1c levels were considered as good (<7.0%) in 60%, fair (7.0-8.0%) in 17%, and poor (>8.0%) in 23%. The mean fasting glucose and HbA1c levels were highest for diabetics with BMI <25.0, suggesting a state of higher severity of disease. Mean insulin and c-peptide levels were highest for diabetics with BMI = 35.0, suggesting a state of insulin resistance.In a nationally representative sample of US adults, the prevalence of diabetes increases with increasing weight classes. Nearly one fourth of adults with diabetes have poor glycemic control and nearly half of adult diabetics are considered obese suggesting that weight loss is an important intervention in an effort to reduce the impact of diabetes on the health care system.
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