rs4771122 Predicts Multiple Measures of Long-Term Weight Loss After Bariatric Surgery

• DOI: 10.1007/s11695-015-1872-7
• Publication Date: 2015-09-03T23:14:44Z
• Authors: Laura J. Rasmusse...; Abigail S. Baldridge; Jennifer A. Pacheco; Sharon A. Aufox; Kwang-Youn A. Kim; Jonathan C. Silve...; Erwin W. Denham; Eric Hungness; Maureen E. Smith; Philip Greenland
• Keywords: Adult; Male; Bariatric Surgery; Middle Aged; Polymorphism, Single Nucleotide; Obesity, Morbid; Mitochondrial Proteins; 03 medical and health sciences; 0302 clinical medicine; Databases, Genetic; Weight Loss; Humans; Female; Eukaryotic Initiation Factors

We examined the association of 34 single nucleotide polymorphisms with weight loss up to 9.5 years after Roux-en-Y surgery. Participants were enrollees in the NUgene biobank with stored DNA and linked electronic health records. Ninety-five self-identified white participants underwent surgery and had follow-up weights obtained between 1 and 9.5 years after surgery. SNP rs4771122 was the variant most significantly associated with long-term weight loss after surgery in a repeated linear mixed model (p = .004) of long-term weight loss. In this model, each additional copy of the minor allele was associated with nearly 5 % greater percentage weight loss. This same SNP was also nominally significantly (p < .05) associated with weight loss trajectories, weight loss nadir, and weight loss 2 years after surgery.