Glycemic Control after Sleeve Gastrectomy and Roux-En-Y Gastric Bypass in Obese Subjects with Type 2 Diabetes Mellitus

• DOI: 10.1007/s11695-017-3061-3
• Publication Date: 2017-12-19T23:57:58Z
• Authors: Ville Wallenius; Eveline Dirinck; Lars Fändriks; Almantas Maleckas; Carel W le Roux; Anders Thorell
• Keywords: Roux-en-Y anastomosis; Sleeve gastrectomy

Roux-en-Y gastric bypass (LRYGB) has weight-independent effects on glycemia in obese type 2 diabetic patients, whereas sleeve gastrectomy (LSG) is less well characterized. This study aims to compare early and later weight-dependent glycemic of LRYGB LSG. Eighteen 15 LSG patients were included the study. Glucose, insulin, GLP-1, GIP levels monitored during a modified 30 g oral glucose tolerance test before surgery days, 3 weeks, 12 months after surgery. Patients self-monitored weeks Postoperative fasting blood decreased similarly both groups (LRYGB vs. SG; baseline—8.1 ± 0.6 8.2 0.4 mmol/l, days—7.8 0.5 7.4 0.3 weeks—6.6 6.6 respectively, P < 0.01 baseline for groups; months—6.6 5.9 0.4, 0.05 0.001 baseline, = ns between at all times). LSG, but not LRYGB, showed increased peak insulin days postoperatively (mean SEM; + 58 14%, 0.01; − 8 17%, ns). GLP-1 higher (AUC; 7525 1258 4779 712 pmol × min, 0.05). did differ. Body mass index (BMI) more than (− 10.1 0.9 7.9 kg/m2, show very similar control, despite lower inferior BMI decrease