Cancer Risk After Bariatric Surgery in a Cohort Study from the Five Nordic Countries

• DOI: 10.1007/s11695-020-04751-6
• Publication Date: 2020-06-13T20:02:32Z
• Authors: Wenjing Tao; Giola Santoni; My von Euler-Chelpin; Rickard Ljung; Elsebeth Lynge; Eero Pukkala; Eivind Ness-Jensen; Pål Romundstad; Laufey Tryggvadottir; Jesper Lagergren
• Keywords: Adult; Male; Original Contributions; Iceland; 610; Bariatric Surgery; Scandinavian and Nordic Countries; Cohort Studies; 03 medical and health sciences; 0302 clinical medicine; Risk Factors; Neoplasms; 617; Humans; Obesity; Registries; Finland; Sweden; 2. Zero hunger; Norway; Obesity, Morbid; 3. Good health; Neoplasm; Scandinavian and Nordic countries; Female; Metabolic surgery

Obesity increases the risk of several cancers, but influence bariatric surgery on individual obesity-related cancers is unclear. This study aimed to assess impact cancer in a multi-national setting.This cohort included all adults with an obesity diagnosis identified from national patient registries Nordic countries (Denmark, Finland, Iceland, Norway and Sweden) 1980 2012. Cancer patients was compared non-operated obesity. Multivariable Cox regression provided adjusted hazard ratios (HRs) 95% confidence intervals (CIs). Age, sex, calendar year, country, length follow-up, diabetes, chronic obstructive pulmonary disease alcohol-related diseases were evaluated as confounders.Among 482,572 participants obesity, 49,096 underwent surgery. Bariatric followed by decreased overall women (HR 0.86, CI 0.80-0.92), not men 0.98, 0.95-1.01). The reduction observed only within first five post-operative years. Among specific tumours, HRs for breast 0.81, 0.69-0.95), endometrial 0.69, 0.56-0.84) non-Hodgkin lymphoma 0.64, 0.42-0.97) female patients, while kidney increased both sexes 1.44, 1.13-1.84).Bariatric may decrease years after be explained women.