Incidence and determinants of high-sensitivity troponin and natriuretic peptides elevation at admission in hospitalized COVID-19 pneumonia patients

• DOI: 10.1007/s11739-020-02498-7
• Publication Date: 2020-09-28T04:02:31Z
• Authors: Luca Arcari; Michelangelo Luciani; Luca Cacciotti; Maria Beatrice Mu...; Valerio Spuntarelli; Eleonora Pistella; Dario Martolini; Daniele Manzo; Mariateresa Pucci; Claudio Marone; Serena Melandri; Gerardo Ansalone; Claudio Santini; Paolo Martelletti; Massimo Volpe; Luciano De Biase
• Keywords: Troponin T

Myocardial involvement in the course of coronavirus disease 2019 (COVID-19) pneumonia has been reported, though not fully characterized yet. The aim present study is to undertake a joint evaluation hs-Troponin and natriuretic peptides (NP) patients hospitalized for COVID-19 pneumonia. In this multicenter observational study, we analyzed data from n = 111 patients. Cardiac biomarkers subgroups were identified according values beyond reference range. Increased NP found 38 56% cases, respectively. As compared those with normal cardiac biomarkers, these older, had higher prevalence cardiovascular diseases (CVD) more severe by CRP d-dimer lower PaO2/FIO2. Two-dimensional echocardiography performed subset (n 24) showed significantly reduced left ventricular ejection fraction elevated (p 0.02), whereas right systolic function (tricuspid annular plane excursion) was both high 0.022 p 0.03, respectively). Both in-hospital mortality 0.001 0.002, On multivariable analysis, independent associations age, PaO2/FIO2 (B 0.419, 0.001; B − 0.212, 0.013; 0.179, 0.037, respectively) age previous CVD 0.480, < 0.253, 0.001, at admission common Independent markers severity underlying might point toward existing different mechanisms leading their elevation setting.