Hemoglobin is associated with hypertension-mediated cardiovascular damages in hypertensive patients with high-altitude polycythemia

• DOI: 10.1007/s11739-024-03800-7
• Publication Date: 2024-11-07T16:57:44Z
• Authors: Xiangyu Yang; Hongwei Li; Jie Zhang; Xiajiao Yang; Qianqiu Che; Zhengyao Cai; Yuting Cao; Yongxing Fu; Jinghua Zhao; Xin Zhang; Xiaoping Chen; Liming Zhao
• Keywords: 03 medical and health sciences; 0302 clinical medicine

High-altitude polycythemia (HAPC) is a pathological state resulting from maladaptation to prolonged high-altitude exposure, posing significant risks the cardiovascular health of highlanders. However, its influence on hypertension-mediated organ damages (HMODs) in hypertensive individuals remains unclear. We recruited patients residing at altitudes above 2500 m for over 3 years. A case-control matching was conducted 1:1 ratio between with and without HAPC, based gender age. Echocardiography, carotid artery ultrasound, brachial flow-mediated dilation (FMD) were measured as HMODs. total 88 included analysis, 44 HAPC HAPC. Patients showed significantly higher hemoglobin (HGB) levels (217.82 ± 17.34 vs. 160.16 13.25, P<0.001), larger left atrium (LA) diameter (35.36 4.25 33.09 3.55, P = 0.008), proportion impaired FMD (95.45% 79.55%, 0.049) compared those No differences found two groups diastolic function parameters, ventricular mass index (LVMI), relative wall thickness (RWT), or intima-media (IMT). After adjusting age, gender, other confounding factors, HGB remained associated LA (β 0.034, 0.023) (OR 1.034, 95% CI 1.001-1.069). age exhibited prevalence Additionally, identified an independent risk factor both increased