Synthesis and characterization of a series of carbamate‐linked cationic lipids for gene delivery

• DOI: 10.1007/s11745-005-1446-5
• Publication Date: 2007-01-08T11:12:08Z
• Authors: Dongliang Liu; ianjun Hu; Weihong Qiao; Zongshi Li; Shubiao Zhan; Lvbo Cheng
• Keywords: Lipidology; Carbamate; Cationic polymerization; Characterization

Abstract A series of pH‐sensitive lipids, 1a‐h [(2,3‐bis‐alkyl‐carbamoyloxy‐propyl)‐trialkylammonium halide] and 2a‐d (1‐dimethylamino‐2,3‐bis‐alkylcarbamoyloxy‐propane), with carbamate linkages between the hydrocarbon chains an ammonium or tertiary amine head, were synthesized for liposome‐mediated gene delivery. The variable length carbon quaternary neutral heads allowed us to identify structure‐function relationship showing how these factors would affect cationic lipid in delivery performance.