2‐Polyunsaturated Acyl Lysophosphatidylethanolamine Attenuates Inflammatory Response in Zymosan A‐Induced Peritonitis in Mice

• DOI: 10.1007/s11745-011-3589-2
• Publication Date: 2011-07-09T15:05:39Z
• Authors: Nguyen Dang Hung; Mee Ree Kim; Dai‐Eun Sok
• Keywords: Zymosan; Lysophosphatidylethanolamine; Extravasation; Lipoxin

Abstract In the present study, anti‐inflammatory action of lysophosphatidylethanolamine (lysoPtdEtn), orally administered, in zymosan A‐induced peritonitis was examined. Oral administration 2‐DHA‐lysoPtdEtn (ED 50 , ~111 μg/kg) or 2‐ARA‐lysoPtdEtn 221 found to inhibit plasma leakage mice treated with A. support this, 2‐polyunsaturated acyl‐lysoPtdEtn diminished formation LTC 4 a lipid mediator responsible for vascular permeability. Next, 110 123 effectively inhibited leukocyte extravasation into peritoneum. Consistent each polyunsaturated‐lysoPtdEtn LTB and 12‐HETE, potent chemotactic factors. Additionally, level pro‐inflammatory (IL‐1 β, IL‐6, TNF‐α NO) lowered remarkably contrast augmentation interleukin IL‐10. Furthermore, 2‐(15‐HETE)‐lysoPtdEtn 2‐(17‐HDHE)‐lysoPtdEtn, 15‐lipoxygenation product 2‐DHA‐lysoPtdEtn, respectively, were more than corresponding lysoPtdEtn, suggesting 2‐acyl‐lysoPtdEtn might be expressed through 15‐lipoxygenation. 15‐HETE LXA upgraded accordance an increasing dose 2‐ARA‐lysoPtdEtn. Separately, actions, acyl‐lysoPtdEtns also drastically infiltration later phase peritonitis, indicating that these lipids possess pro‐resolving activity. Taken together, it is suggested polyunsaturated lysoPtdEtns their lipoxygenation derivatives, could classified as lipids.