Chylomicron Formation and Secretion is Required for Lipid‐Stimulated Release of Incretins GLP‐1 and GIP

• DOI: 10.1007/s11745-011-3650-1
• Publication Date: 2012-02-01T07:01:09Z
• Authors: Wendell J. Lu; Qing Yang; Li Yang; Dana Lee; David D’Alessio; Patrick Tso
• Keywords: Chylomicron; Incretin; Gastric inhibitory polypeptide

Abstract Glucagon‐like peptide‐1 (GLP‐1) and glucose‐dependent insulinotropic polypeptide (GIP) are incretins produced in the intestine that play a central role glucose metabolism insulin secretion. Circulating concentrations of GLP‐1 GIP low can be difficult to assay rodents. These studies utilized novel intestinal lymph fistula model we have established investigate mechanism lipid‐stimulated incretin Peak following an enteral lipid stimulus (Liposyn) were significantly higher than portal venous plasma. To determine whether secretion was related chylomicron formation Pluronic L‐81 (L‐81), surfactant inhibiting synthesis, given concurrently with Liposyn. The presence almost completely abolished increase triglyceride seen Liposyn alone ( P < 0.001). Inhibition reduced into compared stimulation = 0.034). effect relative had even greater on secretion, which 0.004). findings dramatic levels support strong link between absorption difference two provides further nutrient‐stimulation is via distinct mechanisms.