Female Mice are Resistant to Fabp1 Gene Ablation‐Induced Alterations in Brain Endocannabinoid Levels
Male
Mice
0303 health sciences
03 medical and health sciences
Arachidonic Acid
Ethanolamines
Animals
Brain
Female
Fatty Acid-Binding Proteins
Endocannabinoids
Glycerides
DOI:
10.1007/s11745-016-4175-4
Publication Date:
2016-07-23T07:22:31Z
AUTHORS (10)
ABSTRACT
Although liver fatty acid binding protein (FABP1, L-FABP) is not detectable in the brain, Fabp1 gene ablation (LKO) markedly increases endocannabinoids (EC) brains of male mice. Since brain EC system females differs significantly from that males, it was important to determine if LKO differently impacted system. did alter levels arachidonic (ARA)-containing EC, i.e. arachidonoylethanolamide (AEA) and 2-arachidonoylglycerol (2-AG), but decreased non-ARA-containing N-acylethanolamides (OEA, PEA) 2-oleoylglycerol (2-OG) potentiate actions AEA 2-AG. These changes potentiating were associated with: (1) a net decrease membrane proteins with uptake synthesis; (2) increase cytosolic chaperones enzymes degradation; or (3) increased receptors (CB1, TRVP1). Instead, reduced opposite responsiveness female loss FABP1 correlated intrinsically lower level livers WT than males. data show mouse endocannabinoid unchanged (AEA, 2-AG) PEA, 2-OG) by complete (LKO).
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