A prospective evaluation of quality of life, psychosocial distress, and functional outcomes two years after radical cystectomy and urinary diversion in 842 German bladder cancer patients

• DOI: 10.1007/s11764-024-01535-0
• Publication Date: 2024-01-30T19:02:24Z
• Authors: Henning Bahlburg; Alina Reicherz; Moritz Reike; Peter Bach; Marius Cristian B...; Karl Heinrich Tully; Florian Roghmann; Joachim Noldus; Guido Müller
• Keywords: Urinary diversion

Abstract Purpose This study aims to evaluate survival, health-related quality of life (HRQoL), psychosocial distress, and functional outcomes after radical cystectomy (RC) urinary diversion for ileal neobladder (INB) or conduit (IC) in a contemporary German cohort bladder cancer patients. Methods Patients undergoing inpatient rehabilitation RC between April 2018 December 2019 one high-volume center were surveyed regarding HRQoL, until two years RC. Results Eight-hundred forty-two patients (683 male, 159 female; 395 INB, 447 IC) included. with an IC suffered more often from locally advanced disease (≥ pT3; 41.4% vs. 24.1%, p < 0.001) lymph node metastases (19.9% 11.8%, = 0.002), resulting worse probability survival (p 0.001). Global HRQoL improved steadily during follow-up, but significant differences subscales persisted cohorts. Multivariable regression analysis identified IC, male sex, patient age ≤ 59 as independent predictors persistent high distress. Almost 42% female reported severe incontinence Most men severely diminished erectile function, even nerve-sparing surgery. Conclusion is comparable the general population. Female should be informed about continence rates. Conversely, educated dysfunction. Aftercare include psycho-oncologic counseling, especially at risk. Implications survivors counseled on long-term distress Closer cooperation urologists psycho-oncologists needed.