Molecular analysis for medicine: a new technological platform based on nanopatterning and label free optical direction

• DOI: 10.1007/s11834-009-0135-0
• Publication Date: 2010-07-01T10:34:38Z
• Authors: J. C. Cau; H. Lalo; C. Séverac; J. P. Peyrade; E. Trévisiol; V. Leberre; J. M. Francois; C. Vieu
• Keywords: Biochip

In this article, we show that by biopatterning probe molecules at the nanoscale using soft lithography, protein biochips can be produced at a significantly lower cost for their use as a systematic method of molecular analysis for medical diagnosis purposes. The combination of multiplexed nanoscale microcontact printing and label-free optical detection using the principle of light diffraction is implemented for generating engineered glass slides for analysis, and a dedicated diffractive scanner for reading the multiplexed results of an assay.