A combined role for low vitamin D and low albumin circulating levels as strong predictors of worse outcome in COVID-19 patients

• DOI: 10.1007/s11845-022-02952-9
• Publication Date: 2022-02-19T08:09:52Z
• Authors: Gianfranco Sanson; Amedeo De Nicolò; Verena Zerbato; Ludovica Segat; Raffaella Koncan; Stefano Di Bella; Jessica Cusato; Alessandra di Masi; Andrea Palermo; Pietro Caironi; Pierlanfranco D’A...; Roberto Luzzati; Antonio D’Avolio
• Keywords: Serum Albumin

We aimed to assess the combined role of vitamin D and albumin serum levels as predictors COVID-19 disease progression.We conducted a prospective observational study on adult patients hospitalized for SARS-CoV-2 pneumonia (March-September 2020). Vitamin were measured admission. These variables categorized in < 3.5 or ≥ g/dL 30 ng/mL ng/mL. excluded with known bone diseases, renal failure, hypercalcemia and/or treated antiepileptic drugs steroids, who received previous supplementation. A composite outcome including any ventilatory support, PaO2/FiO2 ratio, 60-day mortality was defined.Sixty-nine enrolled, whom 50% non-invasive (NIV) invasive mechanical ventilation (IMV), 10% died, whereas 89% 66% presented low levels, respectively. No correlation between found. In multivariable logistic regression analyses adjusted sex age-corrected comorbidities, having showed significant increased risk all outcomes, namely NIV/IMV (OR 3.815; 95% CI 1.122-12.966; p = 0.032), death 3.173; 1.002-10.043; 0.049) PaO2/FIO2 ≤ 100 3.410; 1.138-10.219; 0.029).The measurement both patients' admission, their evaluation, provides simple prognostic tool that could be employed guide prompt clinical decisions.